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Care should be taken to administer this drug slowly in order to avoid producing an excessive hypotensive effect. Fever should be managed by means of external cooling. Patients should be advised to report the occurrence of GI problems, fever, or heat intolerance promptly since paralytic ileus, hyperthermia, or heat stroke may occur. Patients with arteriosclerosis or with a history of idiosyncrasy to other drugs may exhibit reactions of mental confusion, agitation, disturbed behavior, or nausea and vomiting. Such patients should be allowed to develop a tolerance through the initial administration of a small dose and gradual increase in dose until an effective level is reached. If a severe reaction should occur, administration of the drug should be discontinued for a few days and then resumed at a lower dosage. Psychiatric disturbances can result from indiscriminate use leading to overdosage to sustain continued euphoria.

Seek emergency medical attention

When trihexyphenidyl is used concomitantly with levodopa, the usual dose of each may need to be reduced. Careful adjustment is necessary, depending on side effects and degree of symptom control. Trihexyphenidyl hydrochloride dosage of 3 to 6 mg daily, in divided doses, is usually adequate. II. Plasma levels of the drug, some of its metabolites and prolactin in patients receiving long-term phenothiazine treatment. Exact mechanism of action in parkinsonian syndrome not understood; may result from blockade of efferent impulses and from central inhibition of cerebral motor centers. Animal reproduction studies to evaluate teratogenic and embryotoxic potential have not been conducted with trihexyphenidyl. It is also not known whether trihexyphenidyl can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Trihexyphenidyl should be given to a pregnant woman only if clearly needed.

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This encourages a child to increase movements by presenting interesting activities or objects and giving praise and rewards when a child attempts to use the less-functioning muscles. An uncommon withdrawal syndrome following abrupt withdrawal of Phenelzine sulfate has been infrequently reported. Signs and symptoms of this syndrome generally commence 24 to 72 hours after drug discontinuation and may range from vivid nightmares with agitation to frank psychosis and convulsions. This syndrome generally responds to reinstitution of low-dose Phenelzine sulfate therapy followed by cautious downward titration and discontinuation.

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Certain kinds of surgery, which may sometimes be used for a child with severe problems. Symptoms may include agitation or jitteriness and sometimes insomnia. These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms. Dosage should not be increased until these side effects have subsided. Gases flatulence. The gases create permanent pressure inside the colon and contribute to straining, sometimes intense, to suppress them, particularly when at work or in social settings. So, in addition to all the other indignities related to flatus, you can also add the inevitable enlargement of internal and external hemorrhoids.



Important information

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. Dosage may be increased gradually until symptoms are controlled or until side effects become troublesome. Small or emaciated patients should always be started on the lower dosage. The most serious reactions to Phenelzine sulfate involve changes in blood pressure. Possible urinary hesitancy and retention; a c use with caution and carefully monitor patients with prostatic hypertrophy or obstructive disease of the GU tract. NOTE: Intracranial bleeding has been reported in association with the increase in blood pressure. Please refer to the for information on shortages of one or more of these preparations. Limited experience indicates that phenothiazines are not dialyzable. Dispense in a tight, light-resistant container with a child-resistant closure. To help prevent this effect, drink plenty of fluids unless otherwise directed by your doctor.



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In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully monitored, and dosage adjusted accordingly. Dosage should be increased more gradually in elderly patients. Take this by with or without food, usually every 4 to 6 hours as needed or as directed by your doctor. This medication can be taken with food if upset occurs. Use a medication measuring device to carefully measure the prescribed dose. not use a household spoon. For best results, take with a full glass of water 8 ounces or 240 milliliters. Drink plenty of fluids when you use this medication unless otherwise directed by your doctor. To some degree the function and dysfunction of hemorrhoids is similar to calluses that protect joints from friction damage. And, just as calluses on your palms can bulge, blister, and bleed as the result of too much hard labor, so can hemorrhoids from large stools and straining. No surprise there. Ongoing treatment for CP focuses on continuing and adjusting existing treatments and adding new treatments as needed. Note: Although there is little likelihood of contact dermatitis due to the drug, persons with known sensitivity to phenothiazine drugs should avoid direct contact. V" below the score. Available in bottles of 100, 500 and 1000. Because of increased sedative effects, patients should be cautioned to avoid the use of alcohol or other CNS depressants while taking trihexyphenidyl. Initiate with low dosage; titrate dosage gradually. vidalta



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Take trihexyphenidyl exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Your condition will not improve any faster and your risk of serious side effects may be increased. Also, certain prescription drugs should be avoided. When these abnormal stools get stuck inside the colon or rectum, you may have no choice but to strain, and gradually causing yourself hemorrhoidal disease, anal fissures, and other complications. So if your child has had a faux pas, don't scream at or shame her, otherwise you'll make her too self-conscious, too controlling and, soon, too constipated and prone to straining in order to overcome her "insensitive" anus or overly constrained anal canal. Periodic gonioscopic evaluation and intraocular pressure monitoring recommended. Although disturbances such as galactorrhea, amenorrhea, gynecomastia and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugs. Neither clinical nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time. Potential side effects associated with the use of any atropine-like drugs include constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilation of the pupil, increased intraocular tension, weakness, vomiting, and headache. But several treatment options can make it less severe. There are three common ones. xdir.info butenafine



Use of trihexyphenidyl

Your doctor should check your progress at regular visits, especially for the first few months you take this medicine. This will allow your dosage to be changed as necessary to meet your needs. If you take pramlintide with anticholinergic or antispasmodic medicines, it may slow down the movement of food through your stomach too much and you may develop low blood sugar. Symptoms of low blood sugar include chills, cold sweat, dizziness, drowsiness, shaking, rapid heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. Severe low blood sugar makes it hard to think clearly, drive a car, use heavy machinery, or do other risky activities where you could hurt yourself or others. Use with caution; careful monitoring recommended. Importance of informing patients of other important precautionary information. a See Cautions. These conditions cause a rapid extraction of sodium chloride and fluids from feces. As initial therapy for parkinsonism, 1 mg of trihexyphenidyl hydrochloride may be administered the first day. The dose may then be increased by 2 mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. What should I discuss with my healthcare provider before taking trihexyphenidyl Artane? This therapy can be of great help to children with speech or eating problems. Speech therapy often starts before the child begins school and continues throughout the school years. Sensitivity to the actions of parasympatholytic drugs may increase with age, particularly over the age of 60; therefore, elderly patients generally should be started on low doses of trihexyphenidyl and observed closely. The 1 mg tablets are white film-coated, round, unscored tablets debossed with T3 on one side of the tablet and M on the other side. These medicines may be prescribed together to prevent or treat side effects from your antipsychotic or phenothiazine medicine. In other situations, the combination may increase the likelihood of medicine side effects. Read the Medication Guide that comes with you or your family member's antidepressant medicine. This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. However, parkinsonism and tardive dyskinesia often coexist in patients receiving chronic neuroleptic treatment, and anticholinergic therapy with trihexyphenidyl may relieve some of these parkinsonism symptoms. Trihexyphenidyl is not recommended for use in patients with tardive dyskinesia unless they have concomitant Parkinson's disease.



Trihexyphenidyl dosing information

What should I discuss with my healthcare provider before taking Artane trihexyphenidyl? Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. The elimination of dietary fiber to reduce stool size and density from the diet is a principal strategy for the treatment and prevention of hemorrhoidal disease and related complications. Concurrent use of alcohol or other CNS depressants with trihexyphenidyl may cause increased sedative effects. Initially, 1 mg; if extrapyramidal reactions are not controlled within a few hours, progressively increase dosage until control is achieved. Very disappointed in it and disappointed. Your child may need extra help and encouragement to prepare for added expectations and responsibilities. Adding insult to injury, the acidity can cause even more pain and itching of the already inflamed mucosal membrane of the anal canal or the skin folds in the perianal area caused by external hemorrhoids. indocin



Trihexyphenidyl drug interactions

ARTANE trihexyphenidyl is indicated as an adjunct in the treatment of all forms of postencephalitic, arteriosclerotic, and . It is often useful as when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones. Unlike external hemorrhoids, internal hemorrhoids cause pain indirectly. As with other anticholinergics, trihexyphenidyl may cause suppression of lactation. Therefore, trihexyphenidyl should only be used if the expected benefit to the mother outweighs the potential risk to the infant. Drowsiness and confusion can increase the risk of falling. Endocrine disorders such as underactive thyroid or adrenal insufficiency. These conditions adversely affect the function of smooth muscles of the colon and rectum. What else do I need to know about antidepressant medicines? Ask your pharmacist about the safe use of those products. generic xtane online price



List of trihexyphenidyl side effects

The anal canal expands to 35 mm without apparent harm when there are no enlarged internal hemorrhoids to constrict it. Anything beyond that size is bound to cause pain. If an individual is tense, he or she may not be able to completely relax the external anal muscle, and may experience pain even from smaller stools. But in the great majority of Parkinson's cases, the cause is unknown. It starts with nonstop blinking or eye irritation. Store in a tightly closed container at room temperature between 59-86 degrees F 15-30 degrees C away from light and moisture. not store in the bathroom. Do not freeze. Keep all medicines away from children and pets. Tmax of 43 minutes postdose. Was put on a very low dose. Started out at half a pill 2times a day for a week. Then bumped up to a full pill 2 times a day. I started having headaches at first, then my eyes would start to bun and go blurry. When my tremors started getting worse I looked up side effects and noticed it is a side effect. I shake bad enough without the pill. The rest went down the drain. I will not go back on it. I'd rather just deal with the tremors then to deal with real bad shaking. If you are using the liquid form, use a medication measuring device to carefully measure the prescribed dose. not use a household spoon. If your liquid form is a suspension, shake the bottle well before each dose. Following oral adminstration, onset of action occurs within 1 hour. Avoid becoming overheated. Trihexyphenidyl may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness. Initially, 1 mg on first day. When ARTANE trihexyphenidyl is used concomitantly with levodopa, the usual dose of each may need to be reduced. Careful adjustment is necessary, depending on side effects and degree of control. An ARTANE trihexyphenidyl dosage of 3 to 6 mg daily, in divided doses, is usually adequate. Possible increased ocular tension. a Possible precipitation of glaucoma in patients receiving prolonged therapy. Symptoms of a trihexyphenidyl overdose include large pupils; warm, dry skin; flushed face; fever; dry mouth; fast or irregular heartbeat; anxiety; hallucinations; confusion; agitation; hyperactivity; loss of consciousness; and seizures. Some people, especially children, intentionally withdraw stools to avoid pain. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Phenelzine sulfate and should counsel them in its appropriate use. A patient Medication Guide about "Antidepressant Medicines, Depression and other Serious Mental Illness, and Suicidal Thoughts or Actions" is available for Phenelzine sulfate. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document. Use and dose must be determined by your doctor.



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The actual release of salts may be sudden, without any apparent reason, or preceded by a specific event, such as an airplane flight, certain foods, or medication. Apparently, the changes in atmospheric pressure or some other factors may cause the release of billiary salts during or after the flight. If agents such as sedatives, narcotics, anesthetics, tranquilizers or alcohol are used either simultaneously or successively with the drug, the possibility of an undesirable additive depressant effect should be considered. This medicine may cause your eyes to become more sensitive to light than they are normally. Wearing sunglasses and avoiding too much exposure to bright light may help lessen the discomfort. There is evidence that phenothiazines are excreted in the breast milk of nursing mothers. Because of the potential for serious adverse reactions in nursing infants from trifluoperazine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Trifluoperazine hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine Thorazine fluphenazine Prolixin perphenazine Trilafon haloperidol Haldol thiothixene Navane and others. Patients should be instructed to report promptly the occurrence of headache or other unusual symptoms. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children. Continued When Should I See a Doctor? Neuroleptic Malignant Syndrome NMS has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias. As initial therapy for parkinsonism, 1 mg of Trihexyphenidyl in tablet form may be administered the first day. The dose may then be increased by 2 mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Symptoms of a trihexyphenidyl overdose include large pupils; warm, dry skin; flushed face; fever; dry mouth; fast or irregular heartbeat; anxiety; hallucinations; confusion; agitation; hyperactivity; loss of consciousness; and seizures. What should I avoid while taking Artane trihexyphenidyl? Take this by with or without food as directed by your doctor, usually twice a day. ARTANE trihexyphenidyl should be administered with caution in hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, alcoholics, those who have disease, or those who do manual in a hot environment. may occur more readily when some disturbance of already exists. If there is evidence of anhidrosis, the possibility of should be considered. Dosage should be decreased so that the ability to maintain body heat equilibrium via is not impaired. Severe anhidrosis and fatal hyperthermia have occurred with the use of anticholinergics under the conditions described above. cost zanaflex buy



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The anal canal is small, tight, vulnerable, not easily repairable, and. Phenelzine sulfate is extensively metabolized, primarily by oxidation via monoamine oxidase. After oral administration of 13C 6-Phenelzine, 73% of the administered dose was recovered in urine as phenylacetic acid and parahydroxyphenylacetic acid within 96 hours. Acetylation to N 2-acetylPhenelzine is a minor pathway. National Library of Medicine and Drugs. Limit the use of alcohol and certain other that cause drowsiness. Trihexyphenidyl may be taken with or without meals. Taking trihexyphenidyl with food may lessen stomach upset. ARTANE trihexyphenidyl may be substituted, in whole or in part, for other parasympathetic inhibitors. The usual technique is partial substitution initially, with reduction in the other medication as the dose of trihexyphenidyl HCl is increased. Store away from heat and direct light. Surgery can also relieve the pressure of the artery on your facial nerve that causes a hemifacial spasm. Of the more severe side effects that have been reported with any consistency, hypomania has been the most common. This reaction has been largely limited to patients in whom disorders characterized by hyperkinetic symptoms coexist with, but are obscured by, depressive affect; hypomania usually appeared as depression improved. If agitation is present, it may be increased with Phenelzine sulfate. Hypomania and agitation have also been reported at higher than recommended doses or following long-term therapy. The 5 mg tablets are lavender film-coated, round, unscored tablets debossed with T5 on one side of the tablet and M on the other side. Note: There have been occasional reports of sudden death in patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex. The safe use of Phenelzine sulfate during pregnancy or lactation has not been established. The potential benefit of this drug, if used during pregnancy, lactation, or in women of childbearing age, should be weighed against the possible hazard to the mother or fetus. Agitation, confusion, disorientation, hallucinations, memory loss, and mental changes are more likely to occur in elderly patients, who are usually more sensitive to the effects of antidyskinetics. This, in turn, stimulates a strong straining reflex to suppress the urge sensation again and again, with all the "crap" that follows, particularly for external hemorrhoids. yuasa csa buy metaglip



Trihexyphenidyl adult dosage

What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions? At any moment, you can make a conscious decision to tense the external anal sphincter b and terminate the bowel movement or retain flatus. The ability to keep feces and flatus inside until you consciously decide to move bowels or release gases is an essential social skill acquired by around the 3rd birthday. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom. This medication belongs to the class of drugs known as antispasmodics. Treatment of acute overdose involves symptomatic and supportive therapy. Gastric lavage or other methods to limit absorption should be instituted. A small dose of diazepam or a short-acting barbiturate may be administered if CNS excitation is observed. Phenothiazines are contraindicated because the toxicity may be intensified due to their antimuscarinic action, causing coma. Respiratory support, artificial respiration or vasopressor agents may be necessary. Hyperpyrexia must be reversed, fluid volume replaced and acid-balance maintained. Urinary catheterization may be necessary. Since antidyskinetics tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients. Therefore, not use this product to treat in children younger than 6 years unless specifically directed by the doctor. Neuroleptic Malignant Syndrome NMS has been reported in association with dose reduction or discontinuation of trihexyphenidyl.



Consult your pharmacist for further advice

Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to health care providers. Such monitoring should include daily observation by families and caregivers. Prescriptions for Phenelzine sulfate should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose. United States. Women are twice as likely to get it as men. Minor side effects, such as dryness of the mouth, blurred vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients. These sensations, however, are much less troublesome with trihexyphenidyl than with belladonna alkaloids and are usually less disturbing than unalleviated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses. Internal hemorrhoids do not cause pain, unless they prolapse outside the anus. Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether Trihexyphenidyl HCl may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If Trihexyphenidyl HCl tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water. If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. The patient should be carefully monitored, since recurrences of NMS have been reported. The spasm of the anal sphincter may cause the thrombosis of underlining hemorrhoidal veins, which in turn may cause new external hemorrhoids, or aggravate existing ones. Drugs which lower the seizure threshold, including phenothiazine derivatives, should not be used with metrizamide. As with other phenothiazine derivatives, trifluoperazine hydrochloride should be discontinued at least 48 hours before myelography, should not be resumed for at least 24 hours post procedure and should not be used for the control of nausea and vomiting occurring either prior to myelography or post procedure with metrizamide. Medicines, which can help control some of the symptoms of CP and prevent complications. Edema of the glottis. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. is doxylamine available in generic form



About trihexyphenidyl

If you are prescribed this on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Multiple dose pharmacokinetics have not been studied in man. The total daily intake of trihexyphenidyl is tolerated best if divided into 3 doses and taken at mealtimes. Possible mental confusion, disorientation, agitation, hallucinations, and psychotic-like symptoms. We will not share your email with anyone. divalproex



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Salmonella and Shigella, and pseudomembranous colitis due to broad-spectrum antibiotics. Other symptoms and complications such as fever, shedding of organisms and extraintestinal illness may also be increased or prolonged. In general, because antiperistaltic agents decrease gastrointestinal motility, they may delay the excretion of infective gastroenteric organisms or toxins and should be used cautiously in patients with any infectious diarrhea, particularly if accompanied by high fever or pus or blood in the stool. Some cough and cold and other combination products may occasionally include antimuscarinic agents for their drying effects and may, therefore, require careful selection when necessary.

Trihexyphenidyl warnings

Many adults with CP get jobs if they have good support from their family and community. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water. Isolated instances of suppurative parotitis secondary to excessive dryness of the mouth, skin rashes, dilatation of the colon, paralytic ileus, and certain psychiatric manifestations such as delusions, hallucinations, and paranoia, all of which may occur with any of the atropine-like drugs, have been reported rarely with trihexyphenidyl.

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If hypotension occurs from parenteral or oral dosing, place patient in head-low position with legs raised. If a vasoconstrictor is required, norepinephrine bitartrate and phenylephrine hydrochloride are suitable. Other pressor agents, including epinephrine, should not be used as they may cause a paradoxical further lowering of blood pressure. It is sometimes possible to maintain the patient on a reduced ARTANE trihexyphenidyl dosage after the reactions have remained under control for several days. Instances have been reported in which these reactions have remained in for long periods after ARTANE trihexyphenidyl therapy was discontinued.

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Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether trihexyphenidyl may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If trihexyphenidyl tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.

Taking synthetic or fiber-based bulking laxatives. This is why indigestible fiber in foods and laxatives is universally referred to by doctors as a "bulking agent. Clinical studies of Phenelzine sulfate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. fluconazole

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